Better API Science.
Reliable American Supply.
Best-in-class drug-substance (API & HPAPI) development and GMP manufacturing for complex chemistries and accelerated timelines, from preclinical through commercial supply.
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Discovery Chemistry
Learn more about Discovery ChemistryWhether for in-process, release, or stability testing, Wilmington PharmaTech provides a comprehensive suite of analytical testing capabilities, including:
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Solid State Chemistry
Learn more about Solid State ChemistryWhether for in-process, release, or stability testing, Wilmington PharmaTech provides a comprehensive suite of analytical testing capabilities, including:
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Modi nostrum, facilis doloribus ipsam doloremque quod nisi, voluptate sit assumenda exercitationem eos ea consequatur.
Sunt necessitatibus et ducimus labore! Tempora error beatae aliquid, libero magni reiciendis esse dolores id.
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Development Services
Learn more about Development ServicesWhether for in-process, release, or stability testing, Wilmington PharmaTech provides a comprehensive suite of analytical testing capabilities, including:
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Iure nam cumque magnam maiores, non asperiores?
Modi nostrum, facilis doloribus ipsam doloremque quod nisi, voluptate sit assumenda exercitationem eos ea consequatur.
Sunt necessitatibus et ducimus labore! Tempora error beatae aliquid, libero magni reiciendis esse dolores id.
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cGMP Manufacturing
Learn more about cGMP ManufacturingWhether for in-process, release, or stability testing, Wilmington PharmaTech provides a comprehensive suite of analytical testing capabilities, including:
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Modi nostrum, facilis doloribus ipsam doloremque quod nisi, voluptate sit assumenda exercitationem eos ea consequatur.
Sunt necessitatibus et ducimus labore! Tempora error beatae aliquid, libero magni reiciendis esse dolores id.
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Analytical Services
Learn more about Analytical ServicesWhether for in-process, release, or stability testing, Wilmington PharmaTech provides a comprehensive suite of analytical testing capabilities, including:
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Modi nostrum, facilis doloribus ipsam doloremque quod nisi, voluptate sit assumenda exercitationem eos ea consequatur.
Sunt necessitatibus et ducimus labore! Tempora error beatae aliquid, libero magni reiciendis esse dolores id.
Attending DCAT? Book a meeting with us during the event
Custom synthesis for small molecule projects, including peptides, with integrated, end-to-end support, from lead generation to method and process development, process scale-up, and GMP manufacturing.
From our DuPont/Merck roots and through 20+ years of experience with over 200 INDs, thousands of clinical and commercial batches, and multiple commercial products, as well as recent lab, manufacturing, and HPAPI expansions, Wilmington PharmaTech is ready to solve your complex challenges and accelerate your projects.
Hear our Founder and our Managing Director define what has made Wilmington PharmaTech the small molecule CDMO partner of choice for 20+ years
Integrated Capabilities from Discovery to Commercial Manufacturing
We provide end-to-end support across the entire drug development lifecycle from small molecule APIs, combining the deep science of a Contract Research Organization (CRO) with the fast efficiency of a Contract Development and Manufacturing Organization (CDMO).
Discovery Chemistry
Our seasoned team of medicinal chemistry experts has decades of specialized experience in solving the most complex synthetic challenges.
For more than 20 years, we have designed hundreds of compound analogs and facilitated the synthesis of thousands of variants in support of target identification through lead optimization, across therapeutic areas. Wilmington PharmaTech has participated in rescuing many promising molecules that other contract providers could not develop.
In addition to chemical synthesis solutions, through our partner network, we can also coordinate other services supporting drug metabolism and pharmacokinetics (DMPK), safety, toxicology, product development, and clinical trial support.
Solid State Chemistry
With a wealth of expertise and a combined 20+ years of experience, Wilmington PharmaTech provides comprehensive solid-state chemistry support to optimize your API’s form.
Our services include:
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Salt selection and polymorph screening
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Crystallization optimization
Wilmington PharmaTech has supported the registration of more than 30 patents on behalf of our customers. We have developed more than 300 API candidates, and have supported upwards of 180 investigational new drugs (INDs) and 7 new drug applications (NDAs).
Development Services
We provide Better Science Faster! For more than two decades, Wilmington PharmaTech has invested in creating deep scientific experience in chemical development for IND-enabling, seamless support.
This includes process development and process scale-up, through to GMP supply. Our facility capabilities are purposefully designed to handle the full range of drug substance challenges, including multi-chiral center, OEB 5 HPAPI (e.g., for cytotoxic compounds and antibody-drug conjugate (ADCs)), continuous-flow processing, controlled drug substance (CDS), and peptides.
Our services include:
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API synthesis
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HPAPI dedicated suites
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Process development and optimization
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Process scale-up
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Analytical method development, validation, and ICH stability programs
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API impurity services
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Robust IND-enabling services
We continuously invest to keep our laboratories and GMP suites current and well-equipped, including the recent addition of scalable purification solutions for chiral and achiral separations. Our advanced purification services include racemates and atropisomers with the same cycle used for the purification of both chiral and achiral molecules.
GMP Manufacturing
Proven expertise to accelerate your discovery program through target identification, scaffold synthesis, and lead optimization.
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IND-enabling to small-scale commercial pilot plant for API production
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High-potency API (HPAPI) handling
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Capacity from large-scale GMP labs to pilot suites
We offer flexible sourcing and support options to accelerate milestones, scale up production from pre-clinical to commercial volumes, optimize manufacturing productivity, and drive cost-efficiency.
Analytical Services
Whether for in-process, release, or stability testing, Wilmington PharmaTech provides a comprehensive suite of analytical testing capabilities.
Our services include:
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Analytical method development and validation
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Full GMP release for both clinical and commercial API
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Non-GXP and GLP testing
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Reference Standards, including preparation, qualification, and distribution standards for intermediates and APIs
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Identification of impurities and preparation for qualification, retesting, and distribution of impurity standards
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Full ICH stability studies, including trace impurity analysis
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Designated QA office and documentation storage
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Genotoxicity impurity services including: assessment reports; reference compounds; Ames test (via partner); control strategies; analytical method development, qualification and validation; sub-ppm trace impurity analysis for RSMs, APIs and intermediates; final technical reporting.
We continuously invest to keep our laboratories and GMP suites current and well-equipped, including the recent addition of scalable purification solutions for chiral and achiral separations. Our advanced purification services include racemates and atropisomers with the same cycle used for the purification of both chiral and achiral molecules.
US Facilities Built for Complex API and HPAPI Programs
Wilmington PharmaTech’s FDA-inspected Delaware campus, a former DuPont/Merck site, combines discovery and development labs, scalable manufacturing through commercial scale, advanced analytics, and HPAPI-ready suites to support fast-moving and complex small-molecule programs. Our integrated facilities are built to reduce risk, streamline scale-up, and support critical IND and commercial milestones.
Development labs for API synthesis, purification, and scale-up
Dedicated high-potency suites for cytotoxic and HPAPI needs
Commercial-scale GMP manufacturing up to 750 gallon batch capacity
Experience That Shows Up in Results
Wilmington PharmaTech results are grounded in a long-standing legacy of complex chemistry in Wilmington, Delaware. The company draws from decades of scientific rigor, process knowledge, and manufacturing discipline to build on a strong track record of success in helping pharma innovators develop, rescue, advance, and launch multiple new medicines.
20+ years
of GMP manufacturing
1000+ API
candidates developed
160+ patents
filed for clients
200+ IND
submissions supported
This foundation is now being extended through continued investment in people, facilities, and capabilities. Backed by Curewell’s recent strategic investment, Wilmington PharmaTech is expanding capacity and strengthening its position as a US-based partner for increasingly complex and high-potency programs through commercial scale.
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